Addai was selected in the first round (30th Overall) of the 2006 NFL Draft by the Colts.On November 4, 2007, in a Week 9 game against the New England Patriots, Addai became the first Indianapolis Colt ever to gain 100 yards receiving and 100 yards rushing in one game.On November 1, 2009, in a game against the San Francisco 49ers, Addai completed his first professional pass, a touchdown to Reggie Wayne.